Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year
نویسندگان
چکیده
منابع مشابه
Surgical treatment of male pattern baldness.
1 Chandler JR. Malignant otitis externa. Laryngoscope 1968;78:1257-94. 2 Chandler JR. Pathogenesis and treatment of facial paralysis due to malignant otitis externa. Ann OtolRhinol Laryngol 1972;81:648-58. 3 SchwartzGA, BlumenkrantzMJ, StudmakerWHL. Neurologiccomplicationsofmalignantotitis extema. Neuroloz 1971;21:1077-84. 4 Joachims HZ. Malignant external otitis in children. Arch Otola,yngol 1...
متن کاملGenetic basis of male pattern baldness.
Common pattern baldness (androgenetic alopecia) is the most common form of hair loss in humans. In Caucasians, normal male hair loss, commonly known as ‘‘male pattern baldness’’ (MPB; MIM 109200), is noticeable in about 20% of men aged 20, and increases steadily with age, so that a male in his 90s has a 90% chance of having some degree of MPB. In addition to being among the most common natural ...
متن کاملGenetic prediction of male pattern baldness
Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x...
متن کاملUntargeted metabolomics.
Along with genes and proteins, metabolites play important roles in sustaining life. Their functions include "primary" functions in metabolism and energy storage, as well as "secondary" functions in cell-to-cell signaling, metal acquisition, and virulence. There remains much to be learned about the in vivo roles of metabolites. Approaches that accelerate measurement of metabolite levels directly...
متن کاملFinasteride treatment and neuroactive steroid formation.
Finasteride is the 5alpha-reductase inhibitor that received clinical approval for the treatment of human benign prostate hyperplasia and androgenetic alopecia. The 5alpha-reductase is enzyme responsible for the reduction of testosterone to dihydrostestosterone, progesterone to dihydroprogesterone and deoxycorticosterone to dihydrodeoxycorticosterone, steroids modulating the action of gamma-amin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Metabolites
سال: 2020
ISSN: 2218-1989
DOI: 10.3390/metabo10040131